About Bacillus coagulans

Lactobacillus are the first and most common used probiotics. But there's two disadvantage for the use in livestock 

production. First, strictly storage condition, most of the Lactobacillus need to store under refrigeration. Second, lower

recovering rate after pelleting, almost all strain of Lactobacillus are not tolerance high conditioning temperature.

Bacillus coagulans is a Gram-positive, facultative anaerobic, spore-forming, lactic acid producing bacillus. Bacillus 

coagulans has been added by the EFSA to their Qualified Presumption of Safety list and has been approved for 

veterinary purposes as GRAS by the FDA for Veterinary Medicine.

Why choose GBW Bacillus coagulans (CGMCC13044)?

GBW Bacillus coagulans contain spore of Bacillus coagulans CGMCC13044, this strain was well selected by GBW 

Group, followed by massive laboratory and field testing, which has been patent deposited in China General 

Microbiological Culture Collection Center.

lCompared with lactobacillus the spores of GBW Bacillus coagulans protect them against: 

    (1) high temperature and high pressure during pelleting. 

    (2) the attack of acid, digest enzyme, bile in the digestive tract.

lGBW Bacillus coagulans has been proved have excellent lactic acid producing and pathogen inhibition ability 

    compared with Lactobacillus, no matter in the in-vitro or in-vivo condition.

lThe extracellular polysaccharide structure of GBW Bacillus coagulans contain fucose monomer and β-1, 3, β-1, 6 

   glucan glycosidic bond, which has strong immune activate function.

lSecret protease, amylase that improve the digestibility of nutrients in the lower gastrointestinal tract.

lAerobic respiration of Bacillus coagulans can quickly consume oxygen in the intestine, creating an anaerobic 

    environment and promoting the multiplication of beneficial anaerobic bacteria.

After ingested, the spores will mainly germinate in the lower part of ileum, multiply, temporarily colonize and 

execute positive effect mainly in the hindgut.

Effect of GBW Bacillus coagulans on weaned piglets performance

Weaning imposes tremendous stress on piglets and is accompanied by marked changes in gastrointestinal physiology, 

microbiology and immunology. Owing to these changes, the period following weaning is characterized by a high 

incidence of intestinal disturbances with diarrhea and depression of growth performance in piglets.

A filed experiment was conducted on a commercial hog farm in china. The aim of this experiment was to investigate 

the effects of GBW Bacillus coagulans on growth and health performance of weaned piglets.

Results:

Effect of GBW Bacillus coagulans on growth performance of broiler

A filed experiment was conducted on a commercial broiler farm. The aim of this experiment was to investigate the 

effects of GBW Bacillus coagulans (CGMCC13044) on growth performance of broiler.

Results：

Effect of GBW Bacillus coagulans on LPS induced intestinal inflammation of broiler

LPS is the main toxin factor of E. coli and salmonella, which cause livestock enteric disease. The results shows 

that administrate Bacillus coagulans to LPS challenged broiler can down-regulate the mRNA expression of 

Pro-inflammatory factor, mitigate intestinal inflammation.

Effect of GBW Bacillus coagulans on Jejunum morphology and cecal colonization of E.coli and 

Lactobacillus in broiler chicken

B. coagulans spores beneficially modulate GI microbiota, by increasing lactic acid bacteria, decreasing E.coli in broiler, and 

increase the villi height thus increase the absorption of nutrients.

Trail design:

One-day old AA broiler chicks were provided by a commercial hatchery. The birds were randomly assigned to the 

two groups (90 birds per group with 4 replicates). Feed and water were given ad libitum.

Control group, no additive.

GBW Bacillus coagulans group, supplemented GBW Bacillus coagulans via drinking water, final concentration is 10⁵ CFU/mL.

Experiment period：42days.

At day 42 randomly select 3 chicks from every replicates and cecal contents were cultured for E.coli and Lactobacillus, 

the segments of jejunum were used to test the Villus height and crypt depth.

Results:

Lengthening of villi increase total luminal villus absorptive area and subsequently result in satisfactory digestive 

enzyme action and higher transport of nutrients at the villus surface. Moreover, the higher villus height to crypt 

depth ratio in the broilers supplement with GBW Bacillus coagulans resulted in a decreased turnover of the 

intestinal mucosa. A slower turnover rate of the intestinal epithelium results in a lower maintenance requirement, 

which can finally lead to a higher growth rate or growth efficiency of the animal.